What Ink Does the Epson EcoTank Pro ET-16600 Use?
Last Updated:Quick answer: The Epson EcoTank Pro ET-16600 uses four Epson 542 pigment ink bottles: Black (T542120-S), Cyan (T542220-S), Magenta (T542320-S) and Yellow (T542420-S). Castle Ink sells compatible 542 Black (130 ml), Cyan, Magenta and Yellow at $10.99 each, or a 542 4-pack for $42.99.
The ET-16600 is the lower-priced of Epson's two wide-format EcoTank Pro all-in-ones. It prints up to 13 x 19 inches like the ET-16650 and takes the same 542 bottles as every EcoTank Pro, including the ET-5850 and ET-5800.
CastleScore · November 2026
69/100 — Situational
Epson EcoTank Pro ET-16600
| Pillar (weight) | Score | What it is based on |
|---|---|---|
| Owner ratings (28%) | — | No U.S. retailer rating with enough reviews we could verify. |
| Expert reviews (18%) | — | No published numeric expert score we could verify for the ET-16600 itself (PCMag rated the step-up ET-16650 4.5/5). |
| Cost per page (24%) | 99 | About 0.17¢ per page blended with our 542 4-pack ($42.99: 7,500 black + 6,000 per color pages at Epson's ratings). |
| Reliability (13%) | 76 | Owner complaints are scattered: occasional slow or stalled network printing and a few early failures |
| Features (12%) | 90 | Prints up to 13 x 19 in.; print, copy, scan, fax; document feeder; auto two-sided printing; 500-sheet paper capacity plus rear feed; Wi-Fi, Ethernet; up to 25 ppm black and 12 ppm color. |
| Value (5%) | — | Not scored without owner ratings |
Limited data: We could not find enough owner ratings or a published expert score for this printer, so those weights are spread across the other pillars. With neither owner ratings nor a published expert score, we cap this printer at 69 (Situational) until better data is available.
Still sold new. Best Buy lists it at $899.99.
CastleScore is Castle Ink’s own editorial rating, built from retailer star ratings, expert reviews, real cost per page and owner complaint patterns, checked November 8, 2026. It is not a customer review. See every ranked printer or how the score works.
The ink, pictured
Epson 542 4-packBlack 130 ml + C/M/Y 70 ml
Epson 542 BlackT542120-S · 130 ml
Epson 542 CyanT542220-S · 70 ml
Epson 542 4-pack
Epson 542 Black
Epson 542 CyanOur own compatible 542 bottles, made in the USA.
What Ink Bottles Does the Epson ET-16600 Take?
| Bottle | Epson part no. | Epson size | Approx. yield (Epson) | Castle Ink option |
|---|---|---|---|---|
| 542 Black (pigment) | T542120-S | 127 ml | ~7,500 pages | Compatible, 130 ml, $10.99 |
| 542 Cyan (pigment) | T542220-S | 70 ml | ~6,000 pages | Compatible, 70 ml, $10.99 |
| 542 Magenta (pigment) | T542320-S | 70 ml | ~6,000 pages | Compatible, 70 ml, $10.99 |
| 542 Yellow (pigment) | T542420-S | 70 ml | ~6,000 pages | Compatible, 70 ml, $10.99 |
| All four | — | — | — | 542 4-pack, $42.99 |
Yields are Epson's letter-size ratings; tabloid and 13 x 19 pages use more ink. The ET-16600 ships with one 127 ml black bottle and one each of the colors. Epson 542 is pigment ink, and EcoTank Pro printers are designed for pigment ink only, so don't use dye or sublimation ink.
What Does ET-16600 Ink Cost per Page?
About 0.15¢ a letter page for black and 0.18¢ per color with our $10.99 bottles, or roughly 0.17¢ blended with the $42.99 4-pack. An 11 x 17 page uses about twice the ink of a letter page, which still comes to well under half a cent.
How Do I Refill the Epson ET-16600?
- Check the ink levels in the tank windows on the front of the printer.
- Open the ink tank cover and unscrew the cap on the color you're filling.
- Hold the 542 bottle upright, remove its cap and seal, and insert the keyed tip into the matching port.
- Let the ink flow until it stops at the upper line, then remove and recap.
- Close the cover and confirm the refill on the control panel if asked.
Which Other Printers Use Epson 542?
The wide-format ET-16650; the letter-size EcoTank Pro ET-5850, ET-5800, ET-5880, ET-5150, ET-5170 and ET-5180; and the WorkForce ST-C5000, ST-C5500, ST-C8000 and ST-C8090. See all Epson 542 ink bottles.
What ET-16600 owners ask
These come from Best Buy, Staples and Adorama reviews and Q&A, answered in our words.
Should I get the ET-16600 or the ET-16650?
Both print 13 x 19 with the same ink. The ET-16650 is faster in color (Epson rates it at 25 color pages a minute against 12 for the ET-16600); pick the ET-16600 if color speed doesn't matter and you'd rather save a few hundred dollars.
Does it scan and fax?
Yes. It prints, copies, scans and faxes, with a document feeder for multi-page originals.
Why is it slow over Wi-Fi?
Some owners report stalled or slow network printing. A wired Ethernet connection and Epson's current driver usually solve it.
ET-16600 quirks worth knowing
- It holds 500 sheets in two front trays, plus a rear feed for specialty paper.
- Epson rates it at up to 25 pages a minute in black and 12 in color.
- It has Wi-Fi, Wi-Fi Direct and Ethernet.
- Like all EcoTanks, it uses a replaceable maintenance box for waste ink.
Frequently Asked Questions
What ink does the Epson ET-16600 use?
Epson 542 pigment ink bottles: Black (T542120-S), Cyan (T542220-S), Magenta (T542320-S) and Yellow (T542420-S).
Does the ET-16600 use the same ink as the ET-16650?
Yes. Both use Epson 542.
Can the ET-16600 print 13 x 19?
Yes. It prints up to 13 x 19 inches (super tabloid).
Other printers that use Epson 542
Epson EcoTank Pro ET-16650 · Epson EcoTank Pro ET-5850 · Epson EcoTank Pro ET-5800 · Epson EcoTank Pro ET-5170
More Epson ink guides: Epson EcoTank ET-15000 · Epson EcoTank Photo ET-8550 · Epson WorkForce Pro WF-7840 · find any printer
Replacing it? Our highest-rated alternatives
- Epson EcoTank ET-2980 (cheapest to run) — CastleScore 90
- Canon PIXMA MegaTank G3290 — CastleScore 88
- Canon imageCLASS MF275dw (laser) — CastleScore 81
Sources
Ratings and prices were checked on November 8, 2026 and will change over time.
Need replacement Epson ink cartridges? Shop Epson ink cartridges at Castle Ink. Compatible, up to 70% less than OEM, and shipped the same day when you order by 4 PM ET.