What Ink Does the HP DeskJet F380 Use?
Last Updated:Quick answer: The HP DeskJet F380 All-in-One uses two cartridges: an HP 21 black and an HP 22 tri-color. For photos you can swap the black for an optional HP 58 photo cartridge. Castle Ink stocks remanufactured HP 21 Black, HP 22 Tri-color, a 21 + 22 combo pack and the HP 58 Photo.
It takes the same black and tri-color as the DeskJet F4180, the DeskJet 3940 and the rest of the F300 series. In Europe the HP 58 is sold as C6658AE, and the high-yield 21XL and 22XL were sold as C9351CE and C9352CE. We couldn't confirm U.S. XL part numbers.
CastleScore · October 2026
64/100 — Situational
HP DeskJet F380 All-in-One
| Pillar (weight) | Score | What it is based on |
|---|---|---|
| Owner ratings (28%) | — | No retailer rating with enough reviews to use. |
| Expert reviews (18%) | 55 | Average of two German-language magazine tests via testberichte.de: Konsument 48/100 and ColorFoto 92/150 (both 2007) |
| Cost per page (24%) | 74 | About 7.5¢ per page blended (black + color) with our remanufactured HP 21 black (190 pages) and HP 22 tri-color (165 pages). |
| Reliability (13%) | 76 | Most-reported problems: paper jams, including jam errors after the paper is cleared; printer showing offline and needing driver reinstalls; ink-level alerts stopping after a reinstall; red cast in photos |
| Features (12%) | 40 | Print, copy, scan over USB. No display, no Wi-Fi, no memory card slots, no document feeder, no auto two-sided printing, no fax. |
| Value (5%) | 70 | Running cost and owner satisfaction |
Limited data: We could not find enough owner ratings for this printer, so that weight is spread across the other pillars.
Discontinued. HP launched the DeskJet F380 All-in-One in August 2006, and Icecat records an HP end-of-life date of October 2008. HP 21 and 22 cartridges are still sold.
CastleScore is Castle Ink’s own editorial rating, built from retailer star ratings, expert reviews, real cost per page and owner complaint patterns, checked October 17, 2026. It is not a customer review. See every ranked printer or how the score works.
The cartridges, pictured
HP 21 + 22 comboBlack + Tri-color
HP 21 BlackC9351AN · ~190 pages
HP 22 Tri-colorC9352AN · ~165 pages
HP 58 PhotoC6658AN · optional
HP 21 + 22 combo
HP 21 Black
HP 22 Tri-color
HP 58 PhotoOur own remanufactured cartridges, photographed in-house.
What Ink Cartridges Does the HP DeskJet F380 Take?
| Cartridge | HP part no. | Approx. yield | Castle Ink option |
|---|---|---|---|
| HP 21 Black | C9351AN | ~190 pages | Remanufactured HP 21 Black |
| HP 22 Tri-color | C9352AN | ~165 pages | Remanufactured HP 22 Tri-color |
| HP 58 Photo (optional) | C6658AN | ~125 photos | Remanufactured HP 58 Photo |
| HP 21 + 22 combo pack | C9509FN | ~190 / 165 pages | Remanufactured 21 + 22 combo |
| HP 21XL Black | See note | ~475 pages | — |
| HP 22XL Tri-color | See note | ~415 pages | — |
HP's launch release calls the HP 58 an optional upgrade to six-ink printing; it goes in the black slot. Sellers rate it at about 125 photos. The XL cartridges are listed in Europe and Asia-Pacific only.
Is HP 21XL Worth It?
We couldn't find a U.S. 21XL or 22XL, so the choice is between HP's standard cartridges and remanufactured ones. On October 17, 2026, Staples listed HP's 21 black at $31.89 (about 16.8¢ a page) and the 22 tri-color at $48.99 (about 29.7¢ a page), out of stock for delivery. 4inkjets listed HP's 58 photo at $39.99, backordered. Our remanufactured HP 21 black is $11.99 (about 6.3¢ a page), the HP 22 tri-color $16.99 (about 10.3¢ a page) and the HP 58 photo $19.95, or $26.99 for the 21 + 22 combo pack.
How Do I Replace the Ink in the HP DeskJet F380?
- Turn the F380 on and open the print cartridge door. Wait for the carriage to move to the center and stop.
- Press down on the old cartridge and pull it out of its slot.
- Unwrap the new cartridge, hold it by the black plastic, and pull off the pink tape. Don't touch the copper contacts or nozzles.
- Slide it into the empty slot (tri-color on the left; black, or the HP 58 photo, on the right) and push it forward until it clicks.
- Close the door. With plain paper loaded, let the printer print its alignment page.
Which Other Printers Use HP 21 and 22?
The DeskJet F300 series (F300, F310, F325, F335, F340, F350, F370, F385 and F390); the DeskJet F2110, F2140, F2180, F2210, F2240, F4135, F4140 and F4180; the DeskJet 3910, 3915, 3930 and 3940; the DeskJet D1311, D1320, D1330, D1341, D1360, D1420, D1430, D1445, D1455, D1520, D1530 and D1560; the DeskJet D2320, D2330, D2345, D2360, D2430, D2445 and D2460; the OfficeJet J3640, J3680 and 4315; the PSC 1410; and the HP Fax 1250.
What DeskJet F380 owners ask
These are the questions that come up most for this printer in HP's support community and owner reviews, answered in our words.
Does the F380 take a photo cartridge?
Yes. HP sold the HP 58 photo cartridge (C6658AN) as an optional upgrade to six-ink printing. It goes in place of the black cartridge.
Why does it still say paper jam after I removed the paper?
Clear jammed paper from the rear or the tray, not the front, and check for scraps near the paper sensor. If the computer still shows a jam, delete the printer in Windows and add it again.
It shows offline even though it's plugged in.
Owners report this, especially on Windows Vista. Reinstall the driver and plug the USB cable straight into the computer rather than a hub.
Can it copy without a computer, or fax?
It copies from its control panel, up to 9 copies at a time. It can't fax, and it has no Wi-Fi, network port or memory card slot.
DeskJet F380 quirks worth knowing
- HP rated it at up to 20 pages a minute in black and 14 in color, in draft mode. Computerwoche found it very slow, taking almost two minutes for a letter page.
- There's no display, just buttons and status lights. Computerwoche noted it has no power switch.
- It holds 100 sheets in a fold-up tray and prints borderless 4x6 photos. Sources disagree on its scan resolution.
- Computerwoche saw a red cast in prints and put running costs at about 7 euro cents a page for black and 9.4 for color.
Frequently Asked Questions
What ink does the HP DeskJet F380 use?
HP 21 black and HP 22 tri-color, with an optional HP 58 photo cartridge.
Does the F380 use the same ink as the F4180 and DeskJet 3940?
Yes. All three take HP 21 and HP 22.
Where does the HP 58 photo cartridge go?
In the right-hand slot, in place of the black cartridge.
Other printers that use HP 21 and 22
More HP ink guides: HP OfficeJet 3830 · HP Envy 5000 · HP OfficeJet Pro 8610 · find any printer
Replacing it? Our highest-rated alternatives
- Epson EcoTank ET-2980 (cheapest to run) — CastleScore 90
- HP Color LaserJet Pro 3201dw (laser) — CastleScore 82
- HP OfficeJet Pro 9125e — CastleScore 79
Sources
Ratings and prices were checked on October 17, 2026 and will change over time.
Need replacement HP ink cartridges? Shop HP ink cartridges at Castle Ink. Remanufactured, up to 70% less than OEM, and shipped the same day when you order by 4 PM ET.